Recently, the creative team here at Speak made the transition to designing in-browser. That means we are, for the most part, abandoning desktop design tools like Photoshop, Illustrator and Sketch. We've thrown off the shackles of flat concepts and moved to interactive prototyping.
While I can't say the transition has been entirely painless, I can definitely say it's been rewarding as well as liberating.
Here is an overview of my journey with designing in-browser.